Engrail Therapeutics
Engrail Therapeutics is a clinical-stage precision-neuroscience pharmaceutical company founded in 2019 and headquartered in San Diego, California. It applies precision chemistry and pharmacology to scientifically validated mechanisms of action, developing targeted small-molecule therapies for neuropsychiatric and neurodevelopmental diseases with significant unmet need — including generalized anxiety disorder, major depressive disorder characterized by anhedonia, post-traumatic stress disorder and rare neurodegenerative conditions. Its lead program, ENX-102, is a highly selective GABA-A alpha-2,3,5 positive allosteric modulator in Phase 2 (the ENCALM trial) for generalized anxiety disorder; ENX-104 is in clinical development for anhedonic depression. The company closed an oversubscribed $157M Series B in March 2024 co-led by F-Prime Capital, Forbion and Norwest Venture Partners, bringing total capital raised since inception past $220M. Engrail publishes no product or developer API; the machine-readable surfaces catalogued here are the public read-only content API and the OAuth-protected Model Context Protocol servers exposed by its corporate website.
Limited machine-readable signal and partial portal coverage — documentation a human can read, but little a machine or agent can consume without scraping.
API Evangelist profiles Engrail Therapeutics the way a machine reads it — 7 machine-readable artifacts across 2 APIs, pulled from the provider's own public surface and indexed so a developer, an analyst, or an AI agent can evaluate it against every other provider on the network.
Every provider in the network is reduced to the same set of machine-readable artifacts — OpenAPI contracts, event specifications, GraphQL schemas, runnable collections, pricing and rate-limit signals, security posture, OAuth scopes, and the agent surfaces (MCP servers and skills) that let software drive the API on its own. We profile them because the interface is the part of a company you can actually inspect: it is a truer signal of what a provider does than any marketing page. From those artifacts we compute the Kin Score — Engrail Therapeutics scores 36.1/100 (thin), with a separate agent-readiness read of 26/100 (agent aware). The full breakdown is below, followed by every artifact we hold — each card links through to its machine-readable definition on apis.io.
Kin Score
This is the API Evangelist rating — a single, repeatable read computed from the artifacts on this page. Green fill is points earned; the red track is points possible, so every bar shows earned-versus-possible at a glance.
Kin Score
How this is scored →scored 2026-08-17 · rubric v0.11.0
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How we profile Engrail Therapeutics
Each block below is one kind of artifact we hold for Engrail Therapeutics. For each we say what it is and why it earns a place in the profile, then list every one we've indexed — capped at two rows, scroll within the panel for the rest.
APIs 2
Each API is captured as its own OpenAPI definition — every operation, parameter, and response. This is the single most useful machine-readable description of what an API does, and it's what lets us score, lint, mock, and generate against it without asking the provider for anything.
Individual APIs this provider publishes, each with its own machine-readable definition.
Engrail Therapeutics Site Content API
The public, anonymously-readable content API exposed by engrail.com at /wp-json/wp/v2. Sixteen read operations over posts, pages, media, categories, tags, comments, and the site...
Engrail Therapeutics MCP Servers
Two live Model Context Protocol servers registered under the `mcp` REST namespace on engrail.com, fronted by RFC 8414 and RFC 9728 OAuth discovery documents at the apex. Both ar...
Open Collections 1
Open, tool-agnostic collections carry the same runnable value as Postman without locking you to one client — the portable, forkable form of the same exercise.
Open, tool-agnostic API collections (OpenAPI-derived and Bruno).
Engrail Therapeutics Site Content API (WordPress REST)
OPEN COLLECTIONMCP Servers 1
Model Context Protocol servers expose these APIs directly to AI agents. We profile them because agent-native access is the fastest-growing way this provider's capabilities actually get used.
Model Context Protocol servers that expose these APIs to AI agents.
engrail-therapeutics-mcp.yml
MCP SERVERSecurity Posture 2
Authentication, domain security, vulnerability disclosure, and trust-center signals — the evidence that a provider takes security seriously enough to document it. We profile it because you can't govern what you can't see.
Authentication, domain security, vulnerability disclosure, and trust-center signals.
Scopes 1
OAuth scopes are the vocabulary of least-privilege access. Profiling them shows exactly what an integration — or an agent acting on a user's behalf — is allowed to do.
OAuth scopes governing access to this provider's APIs.
Resources
Every other property we hold for Engrail Therapeutics — documentation, portals, status pages, policies, and corporate surface — grouped by the job it does, following the integrator's arc from getting started to running in production.
Agent Surfaces 3
MCP servers, agent skills, and machine-readable catalogs
Design & Contract 3
Pagination, idempotency, versioning, errors, and events
Access & Security 3
Authentication, authorization, and security posture
Operate 1
Status, limits, changes, and where to get help
Commercial 3
Pricing, plans, and the legal terms of use
Company 7
The organization behind the API
Scroll within the panel for all 7 ·
Other 2
Properties that don't map to a standard resource type
← All providers · Data indexed from github.com/api-evangelist/engrail-therapeutics · machine-readable index on apis.io
This is an independent, third-party profile of Engrail Therapeutics, published by API Evangelist. We do not operate, host, resell, or support these APIs, and we are not affiliated with or endorsed by the company unless stated above. Everything here is built from publicly available information — the company's own site, developer portal, documentation, public repositories, and the specifications it publishes for public use. Nothing is obtained by breaching a system, defeating an access control, or using credentials.
The Kin Score and Agent Readiness rating are independently calculated assessments of a company's public API artifacts, scored against a published rubric. They are not certifications, endorsements, security assessments, or audits.
Corrections, re-scores, and removal are free — no partnership or purchase required, and you do not need to justify the request. A removed company is recorded as unrated, never scored zero for having asked. Acknowledgement within one business day; removal within two.
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