HotSpot Therapeutics
HotSpot Therapeutics is a clinical-stage biopharmaceutical company headquartered in Boston, Massachusetts, pioneering allosteric drug discovery by targeting "natural hotspots" — the regulatory on/off switches on proteins. Its Smart Allostery platform combines AI-driven mining of large, diverse structural and biological data sets with a tailored pharmacology toolkit and bespoke medicinal chemistry to design first-in-class oral small molecules, and has been applied across E3 ligases, kinases and transcription factors. The company has raised roughly $190M across Series A, B and C financings and advanced its lead candidate HST-1011, an oral allosteric CBL-B inhibitor, into first-in-human dosing for cancer, alongside programs in autoimmune disease. HotSpot sells medicines and research collaborations, not software: it publishes no public developer program, API, SDK or machine-readable contract of any kind.
Index entry only — little beyond a description and a link, and nothing machine-readable enough for an agent to act on without a human reading the site first.
API Evangelist profiles HotSpot Therapeutics the way a machine reads it — 1 machine-readable artifact, pulled from the provider's own public surface and indexed so a developer, an analyst, or an AI agent can evaluate it against every other provider on the network.
Every provider in the network is reduced to the same set of machine-readable artifacts — OpenAPI contracts, event specifications, GraphQL schemas, runnable collections, pricing and rate-limit signals, security posture, OAuth scopes, and the agent surfaces (MCP servers and skills) that let software drive the API on its own. We profile them because the interface is the part of a company you can actually inspect: it is a truer signal of what a provider does than any marketing page. From those artifacts we compute the Kin Score — HotSpot Therapeutics scores 9.4/100 (minimal), with a separate agent-readiness read of 0/100 (human only). The full breakdown is below, followed by every artifact we hold — each card links through to its machine-readable definition on apis.io.
Why this profile is thin
HotSpot Therapeutics is a clinical-stage biopharmaceutical company whose product is an oral small-molecule drug pipeline (HST-1011, a CBL-B allosteric inhibitor), not software — its "Smart Allostery" AI platform is an internal discovery engine with no external interface, no api./docs./developer. host resolves in DNS, every /.well-known/ path 404s, and its only public GitHub repo is a fork of the third-party SETH bioinformatics tool.
This is an honest zero, not a gap in our research. HotSpot Therapeutics does not appear to expose an API, so there is nothing here for us to index and nothing for them to fix.
What we probed
https://www.hotspotthera.com/.well-known/api-catalog→ HTTP 404https://www.hotspotthera.com/llms.txt→ HTTP 404https://hotspotthera.com/.well-known/agent-card.json→ HTTP 404https://api.github.com/orgs/HotSpot-Therapeutics/repos→ HTTP 200
Kin Score
This is the API Evangelist rating — a single, repeatable read computed from the artifacts on this page. Green fill is points earned; the red track is points possible, so every bar shows earned-versus-possible at a glance.
Kin Score
How this is scored →scored 2026-08-24 · rubric v0.12.1
Put this on your own site. The badge is drawn live from HotSpot Therapeutics's current Kin Score — paste it once and it updates itself every time the score is recomputed. It follows your visitor's light or dark setting, and it links back here so anyone who sees it can read the full breakdown.
<!-- Kin Score · API Evangelist -->
<a href="https://providers.apievangelist.com/providers/hotspot-therapeutics/"
title="HotSpot Therapeutics on API Evangelist — API profile and Kin Score">
<img src="https://apis.io/badge/hotspot-therapeutics.svg"
alt="HotSpot Therapeutics Kin Score — API readiness rating by API Evangelist" width="150" height="150" loading="lazy">
</a>[](https://providers.apievangelist.com/providers/hotspot-therapeutics/)<!-- Kin Score · API Evangelist -->
<a href="https://providers.apievangelist.com/providers/hotspot-therapeutics/"
title="HotSpot Therapeutics on API Evangelist — API profile and Kin Score">
<img src="https://apis.io/badge/hotspot-therapeutics/card.svg"
alt="HotSpot Therapeutics Kin Score — API readiness rating by API Evangelist" width="340" height="120" loading="lazy">
</a>More shapes, themes and sizes → · Score as JSON · How badges work
How we profile HotSpot Therapeutics
Each block below is one kind of artifact we hold for HotSpot Therapeutics. For each we say what it is and why it earns a place in the profile, then list every one we've indexed — capped at two rows, scroll within the panel for the rest.
Security Posture 1
Authentication, domain security, vulnerability disclosure, and trust-center signals — the evidence that a provider takes security seriously enough to document it. We profile it because you can't govern what you can't see.
Authentication, domain security, vulnerability disclosure, and trust-center signals.
Resources
Every other property we hold for HotSpot Therapeutics — documentation, portals, status pages, policies, and corporate surface — grouped by the job it does, following the integrator's arc from getting started to running in production.
Build 1
SDKs, sample code, and the tooling you integrate with
Access & Security 1
Authentication, authorization, and security posture
Commercial 2
Pricing, plans, and the legal terms of use
Company 2
The organization behind the API
Other 1
Properties that don't map to a standard resource type
← All providers · Data indexed from github.com/api-evangelist/hotspot-therapeutics · machine-readable index on apis.io
This is an independent, third-party profile of HotSpot Therapeutics, published by API Evangelist. We do not operate, host, resell, or support these APIs, and we are not affiliated with or endorsed by the company unless stated above. Everything here is built from publicly available information — the company's own site, developer portal, documentation, public repositories, and the specifications it publishes for public use. Nothing is obtained by breaching a system, defeating an access control, or using credentials.
The Kin Score and Agent Readiness rating are independently calculated assessments of a company's public API artifacts, scored against a published rubric. They are not certifications, endorsements, security assessments, or audits.
Corrections, re-scores, and removal are free — no partnership or purchase required, and you do not need to justify the request. A removed company is recorded as unrated, never scored zero for having asked. Acknowledgement within one business day; removal within two.
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you will get a person, not a form — we will tell you exactly which public URLs this profile was built from.