Profluent
Profluent is a Berkeley, California AI biology company building frontier protein language models and using them to design functional proteins for therapeutics, gene editing, agriculture, and industrial enzymes. Founded by Ali Madani — previously architect of the ProGen large language model for proteins at Salesforce AI Research — Profluent pairs in-house foundation models with a wet lab to author novel proteins from scratch and validate them experimentally. The company's research has been published in Nature Biotechnology and Nature, and it is best known for OpenCRISPR-1, which it describes as the world's first AI-designed gene editor, released freely for research and commercial use. Profluent also publishes the ProGen3 family of protein generation models, ProseLM for structure-conditioned protein design, the E1 family of protein encoder models, Protein2PAM for CRISPR-Cas PAM specificity prediction, and the CRISPR-Cas Atlas dataset. Commercial partnerships include a multi-target collaboration with Eli Lilly worth up to $2.25 billion, and deals with Ensoma, Corteva, Integrated DNA Technologies, and the Rett Syndrome Research Trust. Profluent is backed by Spark Capital, Insight Partners, Air Street Capital, Altimeter, and Bezos Expeditions. The company does not publish a hosted developer REST API or commercial SDK; its surface area for external builders is the Profluent-AI GitHub organization (model weights and inference code), the Protein2PAM web tool, and partnership engagements.
More than an index entry, but the surface is still mostly links rather than artifacts — the cohort most likely to move a full band from modest, well-targeted work.
API Evangelist profiles Profluent the way a machine reads it — 1 machine-readable artifact, pulled from the provider's own public surface and indexed so a developer, an analyst, or an AI agent can evaluate it against every other provider on the network.
Every provider in the network is reduced to the same set of machine-readable artifacts — OpenAPI contracts, event specifications, GraphQL schemas, runnable collections, pricing and rate-limit signals, security posture, OAuth scopes, and the agent surfaces (MCP servers and skills) that let software drive the API on its own. We profile them because the interface is the part of a company you can actually inspect: it is a truer signal of what a provider does than any marketing page. From those artifacts we compute the Kin Score — Profluent scores 11.5/100 (emerging), with a separate agent-readiness read of 0/100 (human only). The full breakdown is below, followed by every artifact we hold — each card links through to its machine-readable definition on apis.io.
Kin Score
This is the API Evangelist rating — a single, repeatable read computed from the artifacts on this page. Green fill is points earned; the red track is points possible, so every bar shows earned-versus-possible at a glance. Every facet and dimension name is a link: it opens that measurement's page on APIs.io, where the rating runs across the whole catalog — the exact checks that feed it, how every profiled provider distributes on it, and who is at the top of it.
Kin Score
How this is scored →scored 2026-09-08 · rubric v0.20.0
Put this on your own site. The badge is drawn live from Profluent's current Kin Score — paste it once and it updates itself every time the score is recomputed. It follows your visitor's light or dark setting, and it links back here so anyone who sees it can read the full breakdown.
<!-- Kin Score · API Evangelist -->
<a href="https://providers.apievangelist.com/providers/profluent-bio/"
title="Profluent on API Evangelist — API profile and Kin Score">
<img src="https://apis.io/badge/profluent-bio.svg"
alt="Profluent Kin Score — API readiness rating by API Evangelist" width="150" height="150" loading="lazy">
</a>[](https://providers.apievangelist.com/providers/profluent-bio/)<!-- Kin Score · API Evangelist -->
<a href="https://providers.apievangelist.com/providers/profluent-bio/"
title="Profluent on API Evangelist — API profile and Kin Score">
<img src="https://apis.io/badge/profluent-bio/card.svg"
alt="Profluent Kin Score — API readiness rating by API Evangelist" width="340" height="120" loading="lazy">
</a>More shapes, themes and sizes → · Score as JSON · How badges work
How we profile Profluent
Each block below is one kind of artifact we hold for Profluent. For each we say what it is and why it earns a place in the profile, then list every one we've indexed — capped at two rows, scroll within the panel for the rest.
Security Posture 1
Authentication, domain security, vulnerability disclosure, and trust-center signals — the evidence that a provider takes security seriously enough to document it. We profile it because you can't govern what you can't see.
Authentication, domain security, vulnerability disclosure, and trust-center signals.
Resources
Every other property we hold for Profluent — documentation, portals, status pages, policies, and corporate surface — grouped by the job it does, following the integrator's arc from getting started to running in production.
Get Started 1
Portal, sign-up, and the first successful call
Build 7
SDKs, sample code, and the tooling you integrate with
Scroll within the panel for all 7 ·
Access & Security 1
Authentication, authorization, and security posture
Learn 1
Tutorials, courses, talks, and written guidance
Operate 1
Status, limits, changes, and where to get help
Commercial 2
Pricing, plans, and the legal terms of use
Company 8
The organization behind the API
Scroll within the panel for all 8 ·
Other 9
Properties that don't map to a standard resource type
Scroll within the panel for all 9 ·
← All providers · Data indexed from github.com/api-evangelist/profluent-bio · machine-readable index on apis.io
This is an independent, third-party profile of Profluent, published by API Evangelist. We do not operate, host, resell, or support these APIs, and we are not affiliated with or endorsed by the company unless stated above. Everything here is built from publicly available information — the company's own site, developer portal, documentation, public repositories, and the specifications it publishes for public use. Nothing is obtained by breaching a system, defeating an access control, or using credentials.
The Kin Score and Agent Readiness rating are independently calculated assessments of a company's public API artifacts, scored against a published rubric. They are not certifications, endorsements, security assessments, or audits.
Corrections, re-scores, and removal are free — no partnership or purchase required, and you do not need to justify the request. A removed company is recorded as unrated, never scored zero for having asked. Acknowledgement within one business day; removal within two.
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