Reactome
Reactome is a free, open-source, curated, and peer-reviewed biological pathway database. It provides comprehensive pathway data covering human biology and orthologous reactions for over 14 non-human species including mouse, rat, yeast, and fruit fly. The platform exposes two primary REST APIs — the Content Service for querying pathway data, molecular interactions, species comparisons, and reaction network visualization, and the Analysis Service for pathway enrichment analysis of gene and protein identifier lists. Both APIs are freely accessible without authentication, fully documented with OpenAPI (Swagger), and cross-referenced with major biological databases including NCBI, Ensembl, UniProt, KEGG, ChEBI, PubMed, and Gene Ontology. Data is authored by expert biologist researchers and maintained by Reactome editorial staff.
Limited machine-readable signal and partial portal coverage — documentation a human can read, but little a machine or agent can consume without scraping.
API Evangelist profiles Reactome the way a machine reads it — 98 machine-readable artifacts across 23 APIs, pulled from the provider's own public surface and indexed so a developer, an analyst, or an AI agent can evaluate it against every other provider on the network.
Every provider in the network is reduced to the same set of machine-readable artifacts — OpenAPI contracts, event specifications, GraphQL schemas, runnable collections, pricing and rate-limit signals, security posture, OAuth scopes, and the agent surfaces (MCP servers and skills) that let software drive the API on its own. We profile them because the interface is the part of a company you can actually inspect: it is a truer signal of what a provider does than any marketing page. From those artifacts we compute the Kin Score — Reactome scores 35.5/100 (thin), with a separate agent-readiness read of 32/100 (agent aware). The full breakdown is below, followed by every artifact we hold — each card links through to its machine-readable definition on apis.io.
Kin Score
This is the API Evangelist rating — a single, repeatable read computed from the artifacts on this page. Green fill is points earned; the red track is points possible, so every bar shows earned-versus-possible at a glance.
Kin Score
How this is scored →scored 2026-07-27 · rubric v0.5
How we profile Reactome
Each block below is one kind of artifact we hold for Reactome. For each we say what it is and why it earns a place in the profile, then list every one we've indexed — capped at two rows, scroll within the panel for the rest.
APIs 23
Each API is captured as its own OpenAPI definition — every operation, parameter, and response. This is the single most useful machine-readable description of what an API does, and it's what lets us score, lint, mock, and generate against it without asking the provider for anything.
Individual APIs this provider publishes, each with its own machine-readable definition.
Reactome database API
Database info queries
Reactome discover API
Reactome Data: Search engines discovery schema
Reactome diseases API
Reactome Data: Disease related queries
Reactome download API
Methods to download different views of a result
Reactome entities API
Reactome Data: PhysicalEntity queries
Reactome events API
Reactome Data: Queries related to events
Reactome exporter API
Reactome Data: Format Exporter
Reactome identifier API
Queries for only one identifier
Reactome identifiers API
Queries for multiple identifiers
Reactome import API
Imports an external result
Reactome interactors API
Molecule interactors
Reactome mapping API
Identifiers mapping methods
Reactome orthology API
Reactome Data: Orthology related queries
Reactome participants API
Reactome Data: Queries related to participants
Reactome pathways API
Reactome Data: Pathway related queries
Reactome person API
Reactome Data: Person queries
Reactome query API
Reactome Data: Common data retrieval
Reactome references API
Reactome xRefs: ReferenceEntity queries
Reactome report API
Retrieves report files in PDF format
Reactome schema API
Reactome Data: Schema class queries
Reactome search API
Reactome Search
Reactome species API
Species comparison
Reactome token API
Previous queries filter
Scroll within the panel for all 23 ·
Semantic Vocabularies 1
JSON-LD contexts give the data shared meaning across APIs. We profile them because semantics are what let a machine reconcile 'customer' here with 'customer' somewhere else.
JSON-LD contexts and semantic vocabularies used across these APIs.
Reactome Context
JSON-LDSpectral Rules 1
Governance rulesets we run against this provider's specs — the automated checks behind parts of the score. Profiling them makes the quality bar explicit and re-runnable, not a matter of opinion.
Reactome API Rules
SPECTRALJSON Schema 71
Standalone JSON Schema definitions describe the data models behind the API. We profile them so the shapes are validatable on their own — useful long after a single request is forgotten.
Standalone JSON Schema definitions for this provider's data models.
AnalysisResult
JSON SCHEMAAnalysisSummary
JSON SCHEMABin
JSON SCHEMAEntityStatistics
JSON SCHEMAExpressionSummary
JSON SCHEMAExternalAnalysisReaction
JSON SCHEMAExternalAnalysisResult
JSON SCHEMAExternalAnalysisSummary
JSON SCHEMAExternalExpressionSummary
JSON SCHEMAExternalIdentifier
JSON SCHEMAExternalInteraction
JSON SCHEMAExternalInteractor
JSON SCHEMAExternalMainIdentifier
JSON SCHEMAExternalPathwayNodeData
JSON SCHEMAExternalPathwayNodeSummary
JSON SCHEMAExternalSpeciesNode
JSON SCHEMAExternalStatistics
JSON SCHEMAFoundElements
JSON SCHEMAFoundEntities
JSON SCHEMAFoundEntity
JSON SCHEMAFoundInteractor
JSON SCHEMAFoundInteractors
JSON SCHEMAIdentifierMap
JSON SCHEMAIdentifierSummary
JSON SCHEMAMappedEntity
JSON SCHEMAMappedIdentifier
JSON SCHEMAPathwayBase
JSON SCHEMAPathwaySummary
JSON SCHEMAReactionStatistics
JSON SCHEMAResourceSummary
JSON SCHEMASpeciesFilteredResult
JSON SCHEMASpeciesSummary
JSON SCHEMAComponentOf
JSON SCHEMACrossReferenceResult
JSON SCHEMACustomInteraction
JSON SCHEMACustomPsicquicResource
JSON SCHEMADatabaseObject
JSON SCHEMADiagramOccurrencesResult
JSON SCHEMADiagramResult
JSON SCHEMAEntry
JSON SCHEMAEventProjection
JSON SCHEMAFacetContainer
JSON SCHEMAFacetList
JSON SCHEMAFacetMapping
JSON SCHEMAFireworksOccurrencesResult
JSON SCHEMAFireworksResult
JSON SCHEMAGroupedResult
JSON SCHEMAIconPhysicalEntity
JSON SCHEMAInteractor
JSON SCHEMAInteractorEntity
JSON SCHEMAInteractors
JSON SCHEMAPageableObject
JSON SCHEMAPageMapStringCollectionCrossReferenceResult
JSON SCHEMAParticipant
JSON SCHEMAParticipantRefEntities
JSON SCHEMAPathwayBrowserNode
JSON SCHEMAPsicquicResource
JSON SCHEMAResult
JSON SCHEMASchemaCreator
JSON SCHEMASchemaDataCatalog
JSON SCHEMASchemaDataDownload
JSON SCHEMASchemaDataSet
JSON SCHEMASchemaNode
JSON SCHEMAShortCrossReference
JSON SCHEMASimpleDatabaseObject
JSON SCHEMASimpleEventProjection
JSON SCHEMASimpleReferenceObject
JSON SCHEMASort
JSON SCHEMASummary
JSON SCHEMATargetResult
JSON SCHEMATupleResult
JSON SCHEMAScroll within the panel for all 71 ·
Security Posture 1
Authentication, domain security, vulnerability disclosure, and trust-center signals — the evidence that a provider takes security seriously enough to document it. We profile it because you can't govern what you can't see.
Authentication, domain security, vulnerability disclosure, and trust-center signals.
Agentic Access 1
An x-agentic-access contract marks which operations are safe for an agent to run on its own and which need a human in the loop. It is the difference between an API an agent can use and one it can use safely.
Recommended x-agentic-access execution contracts for AI agents.
Resources
Every other property we hold for Reactome — documentation, portals, status pages, policies, and corporate surface — grouped by the job it does, following the integrator's arc from getting started to running in production.
Get Started 1
Portal, sign-up, and the first successful call
Documentation 1
Reference material describing how the API behaves
Agent Surfaces 1
MCP servers, agent skills, and machine-readable catalogs
Design & Contract 1
Pagination, idempotency, versioning, errors, and events
Build 1
SDKs, sample code, and the tooling you integrate with
Access & Security 1
Authentication, authorization, and security posture
Operate 2
Status, limits, changes, and where to get help
Commercial 1
Pricing, plans, and the legal terms of use
Company 3
The organization behind the API
← All providers · Data indexed from github.com/api-evangelist/reactome · machine-readable index on apis.io